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Antibody classification

Using a curated set of 70 non-redundant SARS-CoV-2 spike receptor binding domain (RBD) antibodies, we clustered SARS-CoV-2 RBD-binding antibodies into four classes based on RBD binding determinants. Here we report those classifications, as well as classifications of all other RBD-targeting antibodies with known structures, based on comparison to the reference set. Article PubMed
For RBD-binding antibodies, “Download PDB” gives the curated antibody-RBD complex coordinates rather than the actual PDB structure. For non-RBD antibodies, “Download PDB” gives the actual PDB structure.
Antibody complex classification: A tool for user-uploaded RBD-antibody complex cluster assignment using the set of 70 non-redundent RBD-antibody complexes as a reference.
PDB
Antibody
Class
IGHV gene
IGLV/IGKV gene
Species
Release Date
Download PDB
D1F6
3
IGHV1-2
IGLV1-47
human
2024-05-15
D1F6
3
IGHV1-2
IGLV1-47
human
2024-05-15
D1F6
3
IGHV1-2
IGLV1-47
human
2024-05-15
D1F6
3
IGHV1-2
IGLV1-47
human
2024-05-15
D1F6
3
IGHV1-2
IGLV1-47
human
2024-05-15
H6
3
IGHV3-3
none
alpaca
2024-05-15
B5-5
3
IGHV3-3
none
alpaca
2024-05-08
XBB-4
3
IGHV3-15
IGKV1-39
human
2024-05-08
Beta-49
3
IGHV1-69
IGKV3-42
human
2024-05-08
XBB-6
1
IGHV3-9
IGLV2-14
human
2024-05-08
NbC1
4
IGHV3-3
none
alpaca
2024-05-08
XBB-2
1
IGHV3-66
IGKV1-33
human
2024-05-08
XBB-9
1
IGHV3-53
IGKV1-33
human
2024-05-08
BD55-1205
1
IGHV3-66
IGKV3-42
human
2024-04-24
MO11
SD1
IGHV3-23
IGLV3-21
human
2024-04-24
WRAIR-2123
2
IGHV3-30
IGKV1-33
human
2024-04-17
5817
3
IGHV3-15
IGLV3-19
human
2024-04-17
BA.4-5-9
2
IGHV1-46
IGKV3-11
human
2024-04-03
S309
3
IGHV1-18
IGKV3-20
human
2024-03-27
S309
3
IGHV1-18
IGKV3-20
human
2024-03-27
S2L20
NTD
IGHV3-30
IGKV1-33
human
2024-03-27
S2X303
NTD
IGHV2-5
IGLV3-1
human
2024-03-27
S2L20
NTD
IGHV3-30
IGKV1-33
human
2024-03-27
S2X303
NTD
IGHV2-5
IGLV3-1
human
2024-03-27
SD1-2
3
IGHV4-61
IGLV2-23
human
2024-03-13
CC25.36
4
IGHV3-48
IGLV1-40
human
2024-03-13
CV38-142
3
IGHV5-51
IGKV1-21
human
2024-03-13
CC25.54
4
IGHV4-61
IGKV1-16
human
2024-03-13
CC84.2
4
IGHV1-3
IGKV3-20
human
2024-03-13
CC84.24
4
IGHV3-21
IGLV3-21
human
2024-03-13
SD1-3
3
IGHV3-23
IGLV3-1
human
2024-03-13
CC25.43
3
IGHV3-73
IGKV1-5
human
2024-03-13
002-S21B10
3
IGHV2-5
IGLV2-14
human
2024-03-13
CC25.4
3
IGHV1-2
IGLV1-44
human
2024-03-13
BA.4-5-35
1
IGHV3-66
IGKV3-15
human
2024-02-28
Nanosota-3
3
IGHV3S53
none
alpaca
2024-02-21
Nanosota-3
3
IGHV3S53
none
alpaca
2024-02-21
Nanosota-3
3
IGHV3S53
none
alpaca
2024-02-21
Nanosota-3
3
IGHV3S53
none
alpaca
2024-02-21
Nanosota-4
4
IGHV3-3
none
alpaca
2024-02-21
Nanosota-6
3
IGHV3S53
none
alpaca
2024-02-21
Nanosota-4
4
IGHV3-3
none
alpaca
2024-02-21
Nanosota-4
4
IGHV3-3
none
alpaca
2024-02-21
SARS1-34
3
IGHV4-59
IGKV1-5
human
2024-02-21
BA.2-07
2
IGHV1-69
IGKV1-39
human
2024-02-21
C1
4
IGHV3-3
none
alpaca
2024-02-21
BA.4-5-5
SD1
IGHV4-59
IGLV2-23
human
2024-02-21
Nanosota-5
NTD and SD1
IGHV3S53
none
alpaca
2024-02-21
Nanosota-6
NTD and SD1
IGHV3S53
none
alpaca
2024-02-21
Nanosota-5
NTD and SD1
IGHV3S53
none
alpaca
2024-02-21
Nanosota-6
NTD and SD1
IGHV3S53
none
alpaca
2024-02-21
Nanosota-5
NTD and SD1
IGHV3S53
none
alpaca
2024-02-21
BA.4-5-2
1
IGHV3-30
IGKV3-11
human
2024-02-07
Beta-49
3
IGHV1-69
IGKV3-42
human
2024-02-07
Beta-49
3
IGHV1-69
IGKV3-42
human
2024-02-07
Omi-42
1
IGHV3-9
IGLV2-8
human
2024-02-07
BA.4-5-1
2
IGHV4-39
IGKV1-NL1
human
2024-02-07
EY6A
4
IGHV3-30
IGKV1-39
human
2024-02-07
L4.65
3
IGHV2-5
IGKV3-20
human
2024-01-31
L5.34
3
IGHV3-66
IGKV1-39
human
2024-01-31
L4.65
3
IGHV2-5
IGKV3-20
human
2024-01-31
L5.34
3
IGHV3-66
IGKV1-39
human
2024-01-31
L5.34
1
IGHV3-66
IGKV1-39
human
2024-01-31
L4.65
3
IGHV2-5
IGKV3-20
human
2024-01-31
Bn03
3
IGHV3-23
none
human
2024-01-31
UZGENT_G5
2
IGHV1-2
IGLV2-8
human
2024-01-31
UZGENT_A3
2
IGHV1-2
IGLV2-8
human
2024-01-31
Nanosota-3
3
IGHV3S53
none
alpaca
2024-01-24
Nanosota-3
3
IGHV3S53
none
alpaca
2024-01-24
Nanosota-4
4
IGHV3-3
none
alpaca
2024-01-24
Nanosota-2
3
IGHV3S53
none
alpaca
2024-01-24
N3-1
4
IGHV4-4
IGKV1-21
human
2024-01-17
N3-1
4
IGHV4-4
IGKV1-21
human
2024-01-17
WRAIR-5001
3
IGHV1-46
IGLV3-36
human
2024-01-17
WRAIR-5021
2
IGHV4-99
IGKV1-NL1
rhesus
2024-01-17
BIOLS56
3
IGHV3-43
IGKV1-39
human
2023-12-27
Bn03
3
IGHV3-23
none
human
2023-12-27
n3130v-Fc
3
IGHV3-23
none
human
2023-12-27
n3130v-Fc
3
IGHV3-23
none
human
2023-12-27
UT28K-RD
2
IGHV1-58
IGKV3-42
human
2023-12-27
L5.34
1
IGHV3-66
IGKV1-39
human
2023-12-20
L4.65
3
IGHV2-5
IGKV3-20
human
2023-12-20
IMCAS74
3
IGHV5-51
IGLV1-40
human
2023-12-20
W14
4
IGHV4-59
IGKV1-5
human
2023-12-20
Re21H01
4
IGHV3S53
none
alpaca
2023-12-20
Ma6F06
2
IGHV3-3
none
alpaca
2023-12-20
Re21D01
4
IGHV3S53
none
alpaca
2023-12-20
Re30H02
2
IGHV3-3
none
alpaca
2023-12-20
XG005-VH
3
IGHV2-5
none
human
2023-12-13
CR3022
4
IGHV5-51
IGKV4-1
human
2023-12-13
Nb4
4
IGHV3-3
none
alpaca
2023-12-13
WRAIR-2123
2
IGHV3-30
IGKV1-33
human
2023-12-13
Nb4
4
IGHV3-3
none
alpaca
2023-12-13
XG005-VH
3
IGHV2-5
none
human
2023-12-13
XG005-VH
3
IGHV2-5
none
human
2023-12-13
WRAIR-2134
3
IGHV3-33
IGLV3-1
human
2023-12-13
Nb4
4
IGHV3-3
none
alpaca
2023-12-13
8-9D
1
IGHV3-66
IGKV1-9
human
2023-11-29
Nanobody
2
IGHV3-3
none
alpaca
2023-11-15
pT1696
2
IGHV1-58
IGKV3-42
human
2023-11-08
pT1375
1
IGHV3-53
none
human
2023-11-08
pT1611
1
IGHV3-53
none
human
2023-11-08
pT1631
1
IGHV3-53
none
human
2023-11-08
pT1511
4
IGHV3-9
IGKV2-60
human
2023-11-08
NIV-10
2
IGHV3-7
IGLV2-14
human
2023-11-08
pT1644
1
IGHV3-66
IGKV1-33
human
2023-11-08
pT1610
3
IGHV3-53
human
2023-11-08
Nanobody
2
IGHV3-3
none
alpaca
2023-11-01
N19
2
IGHV3-3
none
alpaca
2023-11-01
pT1375
1
IGHV3-53
none
human
2023-11-01
Nanobody
2
IGHV3-3
none
alpaca
2023-11-01
NIV-11
2
IGHV1-58
IGKV3-42
human
2023-10-25
NIV-11
2
IGHV1-58
IGKV3-42
human
2023-10-25
Nb-015
1
IGHV3-3
none
alpaca
2023-10-18
Nb-021
4
IGHV3S53
none
alpaca
2023-10-18
STI-9167
3
IGHV3-33
IGKV1-39
human
2023-10-11
7B3
2
IGHV1-69
none
human
2023-10-04
14B1
2
IGHV3-43
IGKV3-15
human
2023-10-04
12-16
NTD and SD1
IGHV3-30
IGLV3-1
human
2023-10-04
12-19
NTD and SD1
IGHV3-33
IGKV2S15
human
2023-10-04
SKD
2
IGHV1-7
IGLV1-47
cow
2023-09-20
VHH14
4
IGHV3-3
none
alpaca
2023-09-13
VHH21
3
IGHV3S1
none
alpaca
2023-09-13
P14
4
IGHV3S1
none
alpaca
2023-09-13
COVA309-22
4
IGHV3-33
IGKV1-38
human
2023-09-13
R15-F7
2
IGHV1-69
IGKV1-39
human
2023-09-13
R15
2
IGHV1-69
IGKV1-39
human
2023-09-06
P14
4
IGHV3S1
none
alpaca
2023-09-06
BD-218
2
IGHV4-34
IGKV3-11
human
2023-08-30
BA7535
1
IGHV3-30
IGKV5-2
human
2023-08-30
CC12.3
1
IGHV3-53
IGKV3-20
human
2023-08-23
eCR3022.20
4
IGHV5-51
IGKV4-1
human
2023-08-23
Fab47
2
IGHV1-69
IGKV3-20
human
2023-08-16
NB1C6
3
IGHV3-3
none
alpaca
2023-08-16
NB1B5
4
IGHV3-3
none
alpaca
2023-08-16
7A9
3
IGHV3-3
none
alpaca
2023-08-16
3E2
3
IGHV5-9-1
IGKV4-80
mouse
2023-08-16
8H12
2
IGHV3-38
IGKV6-14
rhesus
2023-08-16
8H12
2
IGHV3-38
IGKV6-14
rhesus
2023-08-16
1C4
3
IGHV9-3-1
IGKV5-43
mouse
2023-08-16
3E2
3
IGHV5-9-1
IGKV4-80
mouse
2023-08-16
1C4
3
IGHV9-3-1
IGKV5-43
mouse
2023-08-16
XMA01
2
IGHV3-64D
IGKV1-21
human
2023-08-16
3E2
3
IGHV5-9-1
IGKV4-80
mouse
2023-08-16
E7
3
IGHV4-59
IGKV2-60
human
2023-08-02
E7
3
IGHV4-59
IGKV2-60
human
2023-08-02
DH1047
4
IGHV1-46
IGKV4-1
human
2023-08-02
DH1338
4
IGHV4-173
1IGKV3S9
rhesus
2023-08-02
NIV-8
3
IGHV3-30
IGLV1-40
human
2023-07-19
ICO-hu23
2
IGHV1-2
IGLV2-14
human
2023-07-19
K202.B
2
IGHV3-23
none
human
2023-07-19
NIV-8
3
IGHV3-30
IGLV1-40
human
2023-07-19
ICO-hu23
2
IGHV1-2
IGLV2-14
human
2023-07-19
XGv282
3
IGHV1-69
IGLV1-44
human
2023-07-12
XGv289
3
IGHV1-46
IGLV1-47
human
2023-07-12
10-5B
2
IGHV3-53
IGKV1-12
human
2023-07-12
S2L20
NTD
IGHV3-30
IGKV1-33
human
2023-07-12
BA.2-07
2
IGHV1-69
IGKV1-39
human
2023-07-05
Nb-C4-225
4
IGHV3-23
none
human
2023-07-05
CC12.1
1
IGHV3-53
IGKV1-9
human
2023-07-05
Nb-C4-240
4
IGHV3-23
none
human
2023-07-05
CC12.1
1
IGHV3-53
IGKV1-9
human
2023-07-05
Nb-C4-255
4
IGHV3-23
none
human
2023-07-05
CC12.1
1
IGHV3-53
IGKV1-9
human
2023-07-05
K202.B
2
IGHV3-23
none
human
2023-07-05
TH236
3
IGHV3-11
IGLV2-14
human
2023-06-28
TH132
1
IGHV3-66
IGKV3-15
human
2023-06-28
TH27
3
IGHV2-5
IGLV1-47
human
2023-06-28
TH272
3
IGHV2-5
IGLV2-14
human
2023-06-28
2A10
1
IGHV3-53
IGKV1-33
human
2023-06-28
TH003
3
IGHV3-23
IGLV2-11
human
2023-06-28
TH027
3
IGHV2-5
IGLV1-47
human
2023-06-28
TH132
1
IGHV3-66
IGKV3-15
human
2023-06-28
TH132
1
IGHV3-66
IGKV3-15
human
2023-06-28
TH236
3
IGHV3-11
IGLV2-14
human
2023-06-28
TH272
3
IGHV2-5
IGLV2-14
human
2023-06-28
TH272
3
IGHV2-5
IGLV2-14
human
2023-06-28
TH281
1
IGHV3-66
IGKV3-15
human
2023-06-28
TH281
2
IGHV3-66
IGKV3-15
human
2023-06-28
D27LEY
4
IGHV1-69
IGLV3-21
human
2023-06-28
TH027
3
IGHV2-5
IGLV1-47
human
2023-06-28
TH281
1
IGHV3-66
IGKV3-15
human
2023-06-28
WRAIR-2134
3
IGHV3-33
IGLV3-1
human
2023-06-28
Ab816
3
IGHV5-51
IGKV1-21
human
2023-06-21
Ab803
2
IGHV3-9
IGKV1-39
human
2023-06-21
E77
2
IGHV2-6-7
IGLV1
mouse
2023-06-21
REGN10987
3
IGHV3-30
IGLV2-14
human
2023-06-21
REGN10987
3
IGHV3-30
IGLV2-14
human
2023-06-21
LM18
4
IGHV3-23
none
human
2023-06-14
Nb136
3
IGHV3-23
none
human
2023-06-14
WRAIR-2151
4
IGHV4-39
IGLV6-57
human
2023-06-14
WRAIR-2063
3
IGHV3-33
IGKV2-30
human
2023-06-14
9A8
3
IGHV3-66
IGKV1-33
human
2023-06-07
9A8
3
IGHV3-66
IGKV1-33
human
2023-06-07
9A8
1
IGHV3-66
IGKV1-33
human
2023-06-07
GH12
4
IGHV3-7
IGLV6-57
human
2023-05-31
CB6-092
1
IGHV3-66
IGKV1-39
human
2023-05-31
CB6-092
1
IGHV3-66
IGKV1-39
human
2023-05-31
10-5B
2
IGHV3-53
IGKV1-12
human
2023-05-31
6-2C
3
IGHV3-30
IGKV1-16
human
2023-05-31
10-5B
2
IGHV3-53
IGKV1-12
human
2023-05-31
6-2C
3
IGHV3-30
IGKV1-16
human
2023-05-31
10G4
2
IGHV3-33
IGKV1D-17
human
2023-05-24
80
2
IGHV1-69
IGKV4-1
human
2023-05-24
25F9
4
IGHV3-15
IGLV1S1
human
2023-05-24
21B6
3
IGHV3-49
IGKV1-16
human
2023-05-24
20A7
3
IGHV3-48
IGKV3-20
human
2023-05-24
10G4
2
IGHV3-33
IGKV1D-17
human
2023-05-24
4G1-C2
3
IGHV3-23
IGKV1-39
human
2023-05-24
P5S-2B10
1
IGHV3-53
IGKV1-33
human
2023-05-24
CR3022
4
IGHV5-51
IGKV4-1
human
2023-05-24
4C12-B12
3
IGHV3-23
IGKV1-39
human
2023-05-24
1D1
1
IGHV3-53
IGKV1-33
human
2023-05-17
3D2
3
IGHV5-51
IGLV1-51
human
2023-05-17
3G10
1
IGHV3-66
IGKV1-9
human
2023-05-17
3C11
3
IGHV3-48
IGKV3-11
human
2023-05-17
12145
NTD
IGHV7-4-1
IGLV1-40
human
2023-05-17
Fab47
2
IGHV1-69
IGKV3-20
human
2023-05-10
MO1
3
IGHV3-9
IGKV1-39
human
2023-05-10
P2S-2E9
3
IGHV2-5
IGLV2-14
human
2023-05-10