Antibody classification

Using a curated set of 70 non-redundant SARS-CoV-2 spike receptor binding domain (RBD) antibodies, we clustered SARS-CoV-2 RBD-binding antibodies into four classes based on RBD binding determinants. Here we report those classifications, as well as classifications of all other RBD-targeting antibodies with known structures, based on comparison to the reference set.
For RBD-binding antibodies, “Download PDB” gives the curated antibody-RBD complex coordinates rather than the actual PDB structure. For non-RBD antibodies, “Download PDB” gives the actual PDB structure.
Antibody complex classification: A tool for user-uploaded RBD-antibody complex cluster assignment using the set of 70 non-redundent RBD-antibody complexes as a reference.